Biografija

Dr  Žarko Barjaktarović je rođen u Podgorici 10.03.1976 gdje je završio osnovnu školu i gimnaziju prirodnog smjera. Diplomirao je biohemiju 2003 god. na katedri za Biohemiju Hemijskog  Fakulteta, Univerziteta u Beogradu. Prvi radni odnos zasniva kao biohemicar u Institutu za Javno Zdravlje Crne Gore. U julu 2004 godine dobija stipendiju za doktorski rad na Univerzitetu „Eberhard Karls“ u Tuebingenu, Njemacka, gdje ubrzo zasniva i radni odnos.  U Tuebingenu je radio kao naučni istraživač na svom doktorskom radu u okviru projekta Njemačke Svemirske Agencije (DLR). Takođe, pored naučno istraživačkog rada je aktivno učestvovao u organizovanju studentskih vježbi u i bio laboratorijski mentor bačelor i master studentima. Dobitnik je priznanja Evropske Svenirske Agencija za izuzetan doprinos u naucno-istrazivackom radu. Nakon odbranjenog doktorata 2008 godine i postdoktorskog rada, u maju 2009 pocinje da radi u naučnom centru za biomedicinska istraživanja Helmholtz Centar u Minhenu sve do sredine 2016 godine. Radio je na tri evropska projekta FP7 programa (CardioRisk, ProCardio i DarkRisk projekti) na Institutu za Biologiju zračenja i Institutu za Farmakologiju i Toksikologiju. Predavao je Master studentima Tehničkog Univerziteta (TU) u Minhenu i bio mentor u laboratorijskom radu nekoliko doktoranata. Objavio je 25 naučnih radova i jednu knjigu, uglavnom na istraživanjima terapije kancera i toksikološkim ispitivanjima kardiovaskularnih oboljenja nastalih radioterapijom. Radovi su objavljeni u referentnim zurnalima visokog impakt faktora i imaju znacajan broj citata (https://www.ncbi.nlm.nih.gov/pubmed/?term=zarko+barjaktarovic).  Autor je nekoliko inovativnih biohemijskih metoda i potencijalnih terapija, koje se nalaze u fazi pretkliničkih ispitivanja. Radio je na nekoliko velikih naučnih projekata Evropske komisije, kao i Njemačkih nacionalnih fondova. U toku rada u Njemackoj, boravio je po nekoliko nedjelja na naucnom radu u Svedskoj, Francuskoj i Japanu. Bio je prezenter na seminarima i konferencijama u mnogim EU zemljama, Americi, Australiji i Rusiji.U Minhenu je 2016 godine specijalizirao oblast „Life Science Management“. Trenutno radi u Agenciji za ljekove Crne Gore na jačanju naučnih kapaciteta Agencije i umrežavanju sa partnerskim institucijama u okviru EU, kao i razvitku regulatornog sistema kontrole bioloških naprednih terapija.  Član je menadžment borda evropskog naučnog projekta „Vaccine Adjuvants“ gdje aktivno učestvuje u okviru svoje naučne ekspertize. Trenutno se bavi aplikacijom metoda sistemske toksikologije na razvitku bioloskih naprednih terapija, kao i instrumentalnih hemijskih metoda  za kontrolu kvaliteta ljekova.  Govori tečno Njemački i Engleski jezik (nivoi C1-C2).

Odabrani naucni radovi:

1: Azimzadeh O, Subramanian V, Ständer S, Merl-Pham J, Lowe D, Barjaktarovic Z, Moertl S, Raj K, Atkinson MJ, Tapio S. Proteome analysis of irradiated endothelial cells reveals persistent alteration in protein degradation and the
RhoGDI and NO signalling pathways. Int J Radiat Biol. 2017 Sep;93(9):920-928. doi: 10.1080/09553002.2017.1339332. Epub 2017 Jul 11. PubMed PMID: 28697312.

2: Simonetto C, Azizova TV, Barjaktarovic Z, Bauersachs J, Jacob P, Kaiser JC, Meckbach R, Schöllnberger H, Eidemüller M. A mechanistic model for atherosclerosis and its application to the cohort of Mayak workers. PLoS One. 2017 Apr 6;12(4):e0175386. doi: 10.1371/journal.pone.0175386. eCollection 2017.
PubMed PMID: 28384359; PubMed Central PMCID: PMC5383300.

3: Badie C, Blachowicz A, Barjaktarovic Z, Finnon R, Michaux A, Sarioglu H, Brown N, Manning G, Benotmane MA, Tapio S, Polanska J, Bouffler SD. Transcriptomic and  proteomic analysis of mouse radiation-induced acute myeloid leukaemia (AML).
Oncotarget. 2016 Jun 28;7(26):40461-40480. doi: 10.18632/oncotarget.9626. PubMed  PMID: 27250028; PubMed Central PMCID: PMC5130020.

4: Barjaktarovic Z, Merl-Pham J, Azimzadeh O, Kempf SJ, Raj K, Atkinson MJ, Tapio S. Low-dose radiation differentially regulates protein acetylation and histone deacetylase expression in human coronary artery endothelial cells. Int J Radiat
Biol. 2017 Feb;93(2):156-164. doi: 10.1080/09553002.2017.1237059. Epub 2016 Oct 21. PubMed PMID: 27653672.

5: Kempf SJ, Janik D, Barjaktarovic Z, Braga-Tanaka I 3rd, Tanaka S, Neff F, Saran A, Larsen MR, Tapio S. Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE-/- Alzheimer's mouse model. Oncotarget. 2016 Nov 1;7(44):71817-71832. doi: 10.18632/oncotarget.12376. PubMed PMID: 27708245; PubMed Central PMCID: PMC5342125.

6: Barjaktarovic Z, Kempf SJ, Sriharshan A, Merl-Pham J, Atkinson MJ, Tapio S. Ionizing radiation induces immediate protein acetylation changes in human cardiac microvascular endothelial cells. J Radiat Res. 2015 Jul;56(4):623-32. doi:
10.1093/jrr/rrv014. Epub 2015 Apr 2. PubMed PMID: 25840449; PubMed Central PMCID: PMC4497387.

7: Bakshi MV, Azimzadeh O, Barjaktarovic Z, Kempf SJ, Merl-Pham J, Hauck SM, Buratovic S, Eriksson P, Atkinson MJ, Tapio S. Total body exposure to low-dose ionizing radiation induces long-term alterations to the liver proteome of
neonatally exposed mice. J Proteome Res. 2015 Jan 2;14(1):366-73. doi: 10.1021/pr500890n. Epub 2014 Oct 17. PubMed PMID: 25299163.

8: Kraemer A, Barjaktarovic Z, Sarioglu H, Winkler K, Eckardt-Schupp F, Tapio S, Atkinson MJ, Moertl S. Cell survival following radiation exposure requires miR-525-3p mediated suppression of ARRB1 and TXN1. PLoS One. 2013 Oct
16;8(10):e77484. doi: 10.1371/journal.pone.0077484. eCollection 2013. PubMed PMID: 24147004; PubMed Central PMCID: PMC3797807.

9: Bakshi MV, Barjaktarovic Z, Azimzadeh O, Kempf SJ, Merl J, Hauck SM, Eriksson  P, Buratovic S, Atkinson MJ, Tapio S. Long-term effects of acute low-dose ionizing radiation on the neonatal mouse heart: a proteomic study. Radiat Environ
Biophys. 2013 Nov;52(4):451-61. doi: 10.1007/s00411-013-0483-8. Epub 2013 Jul 24. PubMed PMID: 23880982.

10: Azimzadeh O, Sievert W, Sarioglu H, Yentrapalli R, Barjaktarovic Z, Sriharshan A, Ueffing M, Janik D, Aichler M, Atkinson MJ, Multhoff G, Tapio S. PPAR alpha: a novel radiation target in locally exposed Mus musculus heart revealed by quantitative proteomics. J Proteome Res. 2013 Jun 7;12(6):2700-14. doi: 10.1021/pr400071g. Epub 2013 Apr 29. PubMed PMID: 23560462.

11: Barjaktarovic Z, Shyla A, Azimzadeh O, Schulz S, Haagen J, Dörr W, Sarioglu H, Atkinson MJ, Zischka H, Tapio S. Ionising radiation induces persistent alterations in the cardiac mitochondrial function of C57BL/6 mice 40 weeks after
local heart exposure. Radiother Oncol. 2013 Mar;106(3):404-10. doi: 10.1016/j.radonc.2013.01.017. Epub 2013 Mar 20. PubMed PMID: 23522698.

12: Yentrapalli R, Azimzadeh O, Barjaktarovic Z, Sarioglu H, Wojcik A, Harms-Ringdahl M, Atkinson MJ, Haghdoost S, Tapio S. Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low-dose rate gamma radiation. Proteomics. 2013 Apr;13(7):1096-107. doi: 10.1002/pmic.201200463. Epub 2013 Mar 4. PubMed PMID: 23349028.

13: Barjaktarovic Z, Anastasov N, Azimzadeh O, Sriharshan A, Sarioglu H, Ueffing  M, Tammio H, Hakanen A, Leszczynski D, Atkinson MJ, Tapio S. Integrative proteomic and microRNA analysis of primary human coronary artery endothelialcells  exposed to low-dose gamma radiation. Radiat Environ Biophys. 2013 Mar;52(1):87-98. doi: 10.1007/s00411-012-0439-4. Epub 2012 Nov 9. PubMed PMID: 23138885.

14: Azimzadeh O, Scherthan H, Yentrapalli R, Barjaktarovic Z, Ueffing M, Conrad M, Neff F, Calzada-Wack J, Aubele M, Buske C, Atkinson MJ, Hauck SM, Tapio S. Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart
tissue reveals immediate mitochondrial impairment after ionising radiation. J Proteomics. 2012 Apr 18;75(8):2384-95. doi: 10.1016/j.jprot.2012.02.019. Epub 2012 Feb 23. PubMed PMID: 22387116.

15: Sriharshan A, Boldt K, Sarioglu H, Barjaktarovic Z, Azimzadeh O, Hieber L, Zitzelsberger H, Ueffing M, Atkinson MJ, Tapio S. Proteomic analysis by SILAC and 2D-DIGE reveals radiation-induced endothelial response: four key pathways. J
Proteomics. 2012 Apr 18;75(8):2319-30. doi: 10.1016/j.jprot.2012.02.009. Epub 2012 Feb 20. PubMed PMID: 22370162.

16: Barjaktarovic Z, Schmaltz D, Shyla A, Azimzadeh O, Schulz S, Haagen J, Dörr W, Sarioglu H, Schäfer A, Atkinson MJ, Zischka H, Tapio S. Radiation-induced signaling results in mitochondrial impairment in mouse heart at 4 weeks after
exposure to X-rays. PLoS One. 2011;6(12):e27811. doi: 10.1371/journal.pone.0027811. Epub 2011 Dec 8. PubMed PMID: 22174747; PubMed Central PMCID: PMC3234240.

17: Azimzadeh O, Scherthan H, Sarioglu H, Barjaktarovic Z, Conrad M, Vogt A,Calzada-Wack J, Neff F, Aubele M, Buske C, Atkinson MJ, Tapio S. Rapid proteomic  remodeling of cardiac tissue caused by total body ionizing radiation. Proteomics.
2011 Aug;11(16):3299-311. doi: 10.1002/pmic.201100178. PubMed PMID: 21751382.

18: Pluder F, Barjaktarovic Z, Azimzadeh O, Mörtl S, Krämer A, Steininger S, Sarioglu H, Leszczynski D, Nylund R, Hakanen A, Sriharshan A, Atkinson MJ, Tapio  S. Low-dose irradiation causes rapid alterations to the proteome of the human
endothelial cell line EA.hy926. Radiat Environ Biophys. 2011 Mar;50(1):155-66.doi: 10.1007/s00411-010-0342-9. Epub 2010 Nov 23. PubMed PMID: 21104263.

19: Azimzadeh O, Barjaktarovic Z, Aubele M, Calzada-Wack J, Sarioglu H, Atkinson  MJ, Tapio S. Formalin-fixed paraffin-embedded (FFPE) proteome analysis using gel-free and gel-based proteomics. J Proteome Res. 2010 Sep 3;9(9):4710-20. doi:  10.1021/pr1004168. PubMed PMID: 20604508.

20: Barjaktarović Z, Schütz W, Madlung J, Fladerer C, Nordheim A, Hampp R. Changes in the effective gravitational field strength affect the state of phosphorylation of stress-related proteins in callus cultures of Arabidopsis
thaliana. J Exp Bot. 2009;60(3):779-89. doi: 10.1093/jxb/ern324. Epub 2009 Jan 6. PubMed PMID: 19129159; PubMed Central PMCID: PMC2652066.

21: Barjaktarović Z, Nordheim A, Lamkemeyer T, Fladerer C, Madlung J, Hampp R. Time-course of changes in amounts of specific proteins upon exposure to hyper-g,  2-D clinorotation, and 3-D random positioning of Arabidopsis cell cultures. J Exp Bot. 2007;58(15-16):4357-63. doi: 10.1093/jxb/erm302. PubMed PMID: 18182437.